Job Information
MD Anderson Cancer Center Postdoctoral Fellow - Critical Care - Research in MDA-On-Site, United States
A Postdoctoral position for an NIH-funded project is available at MD Anderson Cancer Center to study the mechanisms and identify novel adjuvant therapies to promote neutrophil extracellular trap (NET) formation in Chronic Granulomatous Disease (CGD), which is a primary immunodeficiency with defects in reactive oxygen species (ROS) generation capacity of phagocytes resulting in life-threatening acute and recurrent infections. Despite improved prophylaxis with antimicrobials and immunomodulatory agents, severe infections continue to be the main cause of morbidity and mortality in CGD patients. This project will investigate new NET modulation strategies as effective treatment options for CGD and its inflammatory clinical manifestations.
We seek a motivated and technically adept postdoctoral fellow to investigate signaling mechanisms of neutrophil extracellular trap formation in response to FDA-approved drugs and their impact on acute and chronic bacterial infections in preclinical models of CGD. The highly translational project will require a commitment of 3 years that will also include working in close collaboration with investigators at NIH/NIAID and a well-defined cohort of CGD patients at NIH Clinical Center. The position requires hands-on experience in transgenic mouse models of pulmonary infection and disease, isolation, culture, and manipulation of primary immune cells, bacterial propagation techniques, multicolor flow cytometry, microscopy, immunostaining, and basic biochemical techniques. Prior experience in working with neutrophils is desirable but not required.
LEARNING OBJECTIVES
Design and implement research methods, resources, and instrumentation relevant to the assigned projects.
Collect, record, analyze, and prepare research data for presentation in research meetings, conferences, and manuscripts.
Participate in the supervision and training of fellows, residents, students, and volunteer personnel as needed, to increase the research efficiency.
Participate in ordering and procurement of supplies and equipment relevant to the assigned projects.
Play an active role in seeking career and research advice from the PI and other faculty members as appropriate.
ELIGIBILITY REQUIREMENTS
PhD in any discipline of basic biology or health science.
ADDITIONAL APPLICATION INFORMATION
Please send a full CV, a brief statement or cover letter describing career goals, research interests, and experience; and names and contact information of 3 references to JSharma1@mdanderson.org. Review of applications will begin immediately and be considered on a rolling basis. The position is fully funded and may be held for 3-5 years.
POSITION INFORMATION
MD Anderson follows the NIH stipend levels as outlined by the Kirchstein - NRSA (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-23-076.html) . This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.
MD Anderson offers compensated trainees:
Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per week
Group Dental, Vision, Life, AD&D and Disability coverage
Paid Education Vacation and Sick Leave
Paid institutional holidays, wellness leave, childcare leave and other paid leave programs
Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans
Employer paid life, AD&D and an illness-related reduced salary pay program
Health Savings Account and Dependent Care Reimbursement flexible spending accounts
Fertility benefits
State of Texas longevity pay
Extensive wellness, fitness, employee health programs and employee resource groups
FACULTY MENTOR
Jyotika Sharma, PHD