MD Anderson Cancer Center Institute Associate Scientist III – Functional Genomics in Houston, Texas

The Institute Associate Scientist III – Functional Genomics participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients.

The mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics. The CCCT is a ground-breaking translational research team that partners with world-class drug discovery scientists at the Institute for Applied Cancer Science (IACS) along with their industry-modelled in vivo pharmacology unit and state-of-the-art computational biology infrastructure. CCCT's cross-functional teams aim to deliver biological insights regarding genetic and functional contributions that influence tumor response to novel therapeutic agents or regimens. As part of the MD Anderson Cancer Center Moon Shots initiative, the capabilities of the CCCT, in concert with IACS, support the institution's academic and clinical research programs to help us reach our goal of delivering safer, more effective treatments to our patients.

Key Functions

  1. Under minimal supervision contribute to project team activities through laboratory experiments.

  2. Contribute to project team's target discovery, validation and drug discovery efforts.

  3. Utilize common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies to support target validation and drug discovery programs.

  4. Perform common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines.

  5. Utilize siRNA, inducible shRNA, CRISPR, dominant negative methods, and small molecule inhibitors to validate targets and biomarkers.

  6. Assist in the development and utilize molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays to support target validation and/or drug discovery programs.

  7. Perform dose response studies in support of patient stratification and biomarker development.

  8. Provide support for in vivo pharmacokinetic, pharmacodynamic and efficacy studies for target validation and drug discovery efforts.

  9. Assist in analysis of in vivo samples for assessment of pharmacodynamic biomarkers.

  10. Help establish and validate mechanistic and functional cell based studies for evaluating novel therapeutic targets.

  11. Employ safe lab practices.

  12. Maintain research records and laboratory notes

Education

Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Experience

Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.

Preferred: Experience with common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines; experience with complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors; common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies; experience (or willingness to work) with vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer; previous experience dosing animals; and, experience developing and utilizing molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and/or functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays are strongly preferred.

Experience using siRNA, inducible shRNA, dominant negative methods to validate targets; as well as experience with utilizing small molecule inhibitors for target and biomarker validation are preferred.

The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to multitask, work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html