MD Anderson Cancer Center Postdoctoral Fellow in Houston, Texas
A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Shabnam Shalapour. Research in the Shalapour Laboratory focuses on the role of chronic inflammation and adaptive immunity in controlling tumor development and the response of various cancers to therapy. While the research focuses primarily on tumor immunology and immunotherapy, our work also addresses fundamental questions in immunology, immunometabolism, and cancer biology using cutting-edge technology tools including multicolor Flow cytometry, CyTOF, imaging, histology, and large-scale omic analysis, e.g., single-cell RNA and ATAC-seq.
The candidate will work on a project recently awarded by the Melanoma Research Alliance (MRA) Team science award (https://www.curemelanoma.org/research/grants/) collaboratively funded by Brigham and Women's Hospital Harvard University and The University of Texas MD Anderson Cancer Center with Title: Harnessing B cell checkpoints in melanoma. The aim is to study the role of B and plasma cells in melanoma. The focus then is on how to use this information to prevent cancer development and develop novel therapeutic approaches to increase the response to immunotherapy and vaccination (see our recent publications; Semin Immunol. 2021 Feb;52:10147; .PNAS, 2021 Feb 23;118(8):e2025840118, Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9), Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul 16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).
This postdoc fellowship will focus on the role of adaptive immune cells, particularly B cells, in tumor immunology and how chronic inflammation regulates their development and effector function, using bioinformatic tools and genetically engineered mouse models (GEMM) and state-of-the-art immunological and experimental approaches.
Applicants must have a recent PhD degree in a related biomedical field, preferred immunology, or cancer biology with strong interests and self-motivation for research.