MD Anderson Cancer Center Research Assistant I - Sarcoma Medical Oncology in Houston, Texas
The department of Sarcoma Medical Oncology has the mission to deliver the highest quality patient care by providing the most advanced medical therapies, opportunities to participate in clinical trials, and aggressive management of any side effect a patient may encounter. The overall goal is to improve survival and quality of life. Research scientists are working to find better therapies, optimize current therapies, reverse chemotherapy resistance, and gain an understanding of why highly effective therapies work so well.
The primary purpose of the Research Assistant I position is to assist in the discovery and translation of targeted cancer therapy for treatment of sarcoma family tumors. This incumbent will provide technical and coordination skills in carrying out various research projects by providing technical assistance in carrying out various research projects. This incumbent will coordinate procedures and perform technical laboratory duties in accordance with general and/or specific plans.
The salary range is: min-$30,400, mid-$38,000 and max-$45,600.
Coordinates and conducts experiments and carries out research projects in varied areas of chemistry, cancer biology, bioinformatics, or related basic science areas.
Constructs, assembles, and operates laboratory apparatus and equipment.
Reads literature, confirms with superiors regarding new procedures, and modifies them according to the needs of the project.
Records and evaluates data obtained in accordance with methods requested.
Focusing on the signaling cascades responsible for Ewing's sarcoma grown under multiple conditions human tumors, mouse xenografts, in 3D culture, or in monolayers in vitro). These signaling cascades will be measured using Western blot, reverse-phase protein lysate arrays (RPPA), and by gene expression arrays and expression will be compared across the varied in vivo and in vitro settings.
Expression analysis, using the technologies outlined above, will be used to determine biomarkers predictive of a clinical state (good vs. poor clinical response to chemotherapy, or good vs poor prognosis, etc. (Ewing's sarcoma cell lines will be used to evaluate novel biologically targeted therapies intended to disrupt the stimulatory signaling cascades responsible for the cancer phenotype.
Isolation of protein and RNA from clinical specimens and cell lines.
Cell culture including assays for cell proliferation, apoptosis, cell cycle state.
Analysis of expression by Western blot, microarray, RPPA, and flow cytometry.
Preclinical drug evaluation in animal xenograft models.
Collects and organizes information for project reports.
Other duties as required.
Required: Bachelor's degree with major course works in one of the basic sciences.
Preferred: Master's degree with major course works in one of the basic sciences.
Preferred: Some experience in scientific or experimental research work.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html