Job Information
MD Anderson Cancer Center Research on vivo and in vivo models in Houston, Texas
The Guise Laboratory is dedicated to understanding cancer bone metastasis, with a particular focus on the role of TGF-ß (Transforming Growth Factor-beta) in the tumor-bone microenvironment. Cancer-induced bone resorption releases TGF-ß from the bone matrix, driving not only bone loss but also impairing other vital organs, including muscle, heart, brain, and pancreatic islets. In particular, TGF-ß contributes to muscle weakness through calcium dysregulation via RyR1 receptors and compromises heart and brain function, affecting cognitive abilities and cardiac contractility.
This position will focus on investigating the mechanisms by which TGF-ß, released during cancer bone metastasis, contributes to the dysfunction of the brain and heart, and developing strategies to mitigate its adverse effects. The lab is also exploring therapeutic approaches such as Rycals to restore muscle function and using low-intensity vibrations to alleviate TGF-ß-induced musculoskeletal toxicity associated with aromatase inhibitors.
The postdoctoral fellow will work under the mentorship of Dr. Guise, conducting independent research using both in vivo and in vitro models.
Key responsibilities will include:
• Designing and performing experiments aimed at understanding the impact of TGF-ß on brain and heart function in the context of cancer bone metastasis.
• Utilizing advanced techniques and methodologies to ensure experimental efficiency and data accuracy.
• Interpreting research results, summarizing data, and drawing scientific conclusions.
• Presenting research findings at lab meetings and potentially at external scientific conferences.
• Contributing to high-quality scientific publications and drafting grant applications.
• Collaborating with lab members and external partners to advance research objectives.
LEARNING OBJECTIVES
The fellowship aims to provide the trainee with a comprehensive understanding of the biology and pathology of cancer bone metastasis, with a particular focus on the following:
• Mechanisms of TGF-ß: Understanding how TGF-ß released from bone metastases contributes to the deterioration of heart and brain function, affecting cognition and cardiac muscle performance.
• Inter-organ communication in cancer: Examining the effects of cancer-induced changes in bone on distant organs, including brain and heart, and exploring potential therapeutic strategies to mitigate these effects.
• Technical skill development: Gaining hands-on experience with imaging techniques such as micro-CT, X-ray, DAX analysis, and histological evaluation for assessing tumor progression and tissue pathology. Gaining the techniques to quantify and classify digital images with BioQuant and other AI software.
• Hypothesis formulation and testing: Developing and validating scientific hypotheses through experimental design and valuable data.
• Scientific communication: Enhancing skills in presenting findings through written publications, oral presentations, and grant writing, with the goal of translating research discoveries into clinical applications.
ELIGIBILITY REQUIREMENTS
Applicants must hold a recent Ph.D. or MD. degree in a field relevant to cancer research, molecular biology, physiology, or a related discipline. The candidate should demonstrate a strong commitment to full-time laboratory research, with aspirations toward an independent academic or research career.
Please note, this appointment is for research training purposes only and does not include any clinical responsibilities. Candidates with an M.D. or equivalent are not permitted to participate in patient care activities during the fellowship.
POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000 (https://trainees.mdanderson.org/apply/mdaPostdoctoralFellowStipendFY24.pdf) . depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits (https://www.utsystem.edu/offices/employee-benefits/insurance-0/eligibility) , including medical, dental, paid time off (https://www.mdanderson.org/about-md-anderson/employee-resources/leave.html) , retirement (https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs) , tuition benefits, educational opportunities, and individual and team recognition12/30/2024