MD Anderson Cancer Center Research Scientist - Leukemia in Houston, Texas
The department of Leukemia is dedicated to quality patient care, innovative research, and developing more effective treatments for all types of leukemia. Clinical research conducted by our faculty and staff consistently translates into new leukemia therapies and advances overall knowledge of the disease.
The Research Scientist applies technical expertise and experience to plan, coordinate, design, supervise and carry out research projects.
The salary range is: min-$53,200, mid-$66,500 and max-$79,800.
- Technical Research
Exploration of mechanism and therapeutic methods associated amyloid aggregation of master gene TP53 and other related mechanism in human Acute Myeloid Leukemia (AML).
Independent animal experimentation using engrafted and transgenic mice models and anti-tumor drugs, analysis of data and application of findings to carry out basic and translational research.
Critical thinking abilities, excellent technical skills, strong work ethic and good organizational and communication skills.
Assist in projects related to the development of optimal in vivo study with particular emphasis on therapeutic evaluation and molecular mechanism of novel agents on AML or CML mouse models in accord with appropriate institutional and regulatory guidelines
Assists in the development of new procedures and improves upon existing techniques relevant to the research.
Write technical reports for grant/patent applications and scientific publications
Design and execution in establishing AML PDX mouse model and transgenic CML models to determine effects of novel drugs, evaluates research data and develops and revises techniques or approaches to work problems in leukemia mouse models, IVIS bioluminescent imaging, tissue collection, and IHC, etc.
The position requires a highly motivated individual with technical expertise in molecular and cell biology to conduct highly ambitious projects aimed at targeting therapy on leukemia cells.
Collaboration with established and committed investigators is a requirement in this interdisciplinary research.
The research involves flowcytometry including CyTOF, cell culture (FACS sorting), signal processing, molecular biology, cancer biology and NSG/NSG-S mouse models.
- Data Analysis:
Application of IVIS bioluminescent imaging for leukemia burden or flow cytometry for leukemia engraftment or IHC for leukemia burden
Design and execution of in vivo studies using AML and CML leukemia mouse model
Proficiency in immunological techniques (immunohistochemistry, immunocytochemistry, flow cytometry, etc.)
Perform animal work and drug treatment studies – dosing (intra-femoral injection, oral gavage, IP or IV), tissue preparation and sample processing
Perform necropsies and tissue collection for histopathological evaluation and IHC
Perform Immunofluorescence and interpretation of results and data analysis
Maintains multiple immunocompromised mouse colonies, including breeding, genotyping, and record keeping for all animal strains
- Lab Development and Oversight:
Perform general laboratory functions and procedures including maintaining inventory and operate, calibrate and perform routine maintenance on specialized equipment, ordering supplies, preparing solutions, maintaining cleanliness and safety in a laboratory setting
Ability to work independently and in a team under minimum supervision
Train and oversee research technicians and students participating in research in the laboratory
Excellent analytical, communication, organizational and presentation skills are essential.
Ability to manage multiple projects simultaneously is essential
Technical proficiency in standard biochemical, cellular and molecular biology techniques and in in vivo/ex vivo/in vitro immunology approaches
Strong results-driven personality with high level of enthusiasm, energy and confidence
Required: PhD in one of the natural sciences or related field or Medical degree
Required: With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html