MD Anderson Cancer Center Jobs

We established a novel mouse coronary atherosclerosis model combining transverse aortic coarctation (TAC) and a hypercholesteremia mice, as we reported in 18. To minimize the direct effect of pressure overload on cardiac function, we evaluated coronary atherosclerosis at 4 weeks after TAC instead of 8 to 25 weeks after TAC as Marino et al. reported101. We observed not only coronary atherosclerosis but also an increase of vessel wall thickness with perivascular fibrosis and infiltration of myeloid cells (MCs) into perivascular lesions102-104, suggesting that the pathology of human coronary lesions after RT is well represented by our new TAC model18. Importantly, we observed that a history of hyperlipidemia was the only independent predictor of major coronary events after RT amongst several cardiac risk factors and pre-existing cardiovascular disease (CVD)1 and in our ongoing cohort study. In this aim, we hypothesize that the depletion of PARP1, the inhibition of glutamine transporter will suppress IR-induced atherosclerosis. Conversely, depleted TOP2ß will accelerate the development of atherosclerosis.

LEARNING OBJECTIVES

We aim to impart knowledge of the anatomy, histology, and physiology of cardiovascular diseases, as well as the methods for their assessment. To facilitate this, we will instruct students on how to isolate tissue specimens, prepare them through fixation, and conduct histological analysis using a variety of staining methods.

Additionally, we have a collection of tissue samples prepared for analysis through our innovative spatial multi-omics research. Students will be guided on the intricacies of analyzing these extensive and intricate datasets, in collaboration with our bioinformatics team.

ELIGIBILITY REQUIREMENTS

For this research endeavor, while a grounding in cellular and molecular biology would be advantageous, it is not a prerequisite for involvement. We place a high value on nurturing talent and are committed to educating individuals at all levels of proficiency in these scientific domains. Above all, we seek individuals who bring a fervent enthusiasm for unraveling the mysteries of human diseases. The most vital attributes we look for in our trainees are an unwavering passion for scientific inquiry and a resolute persistence in their research pursuits. These qualities are paramount as they drive the innovation and dedication necessary to advance in the complex and challenging landscape of medical research. Candidates who exhibit a strong intrinsic motivation and a relentless drive to contribute to our understanding of disease processes will find a welcoming and supportive environment to develop their skills and further their scientific careers.